Articles on PR
HLA antigens in palindromic rheumatism and palindromic
onset rheumatoid arthritis.
Fifty patients who presented with typical palindromic rheumatism of at least 6
months' duration were tissue-typed for HLA A, B, C antigens. DR typing was also
performed but was not possible for technical reasons in three patients.
Twenty-three patients who had progressed to definite or classical rheumatoid
arthritis (RA) after a mean interval of 5 years were compared with 20 patients
whose palindromic attacks had persisted over a similar period. Both groups
showed a significantly higher frequency of DR4 antigen than a control
population. The RA group also showed an increased frequency of DR1. There was no
significant difference in the frequency of DR4 or any other DR antigen between
the two patient groups. The frequency of B27 antigen was significantly higher in
the palindromic group compared with the controls. It is suggested that although
DR4 may be associated with a tendency to inflammatory joint problems,
environmental or other unrelated genetic factors may be more important in
determining the progression of palindromic rheumatism to RA.
PMID: 3490893 [PubMed - indexed for MEDLINE]
Antiphospholipid syndrome and palindromic rheumatism: a
new possible association.
Rheumatology Outpatient Clinics, Barzilai Medical Centre, 3 Histadrut St.,
Ashkelon, and Sourasky Medical Centre, Tel Aviv University, Israel. firstname.lastname@example.org
OBJECTIVE: The aim of this study was to report six patients with palindromic
rheumatism (PR) in whom signs, symptoms, and/or serologic evidence of
antiphospholipid syndrome (APS) developed. METHODS: The medical histories of the
patients were reviewed with special emphasis on age, gender, duration of PR, and
lapse of time until antiphospholipid antibodies were detected or APS was
diagnosed. Three representative cases are described. RESULTS: Two patients were
women and four were men. Their mean age was 49.3 years (range 36-80), and the
mean duration of PR was 5.5 years (range 3-8). In all patients, raised titers of
antiphospholipid antibodies were found on two or more occasions. Two patients
developed clinical pictures compatible with APS, two showed symptoms which may
be attributable for APS, and raised titers of antiphospholipid antibodies were
found in only two. CONCLUSION: It seems that the appearance of these two
uncommon conditions together is more than coincidental and may point to a
previously unreported clinical association.
PMID: 16189657 [PubMed - indexed for MEDLINE]
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